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Research Corner

Cardiology faculty, private attendings join in study

The Cedars-Sinai Heart Institute is helping attending cardiologists and faculty physicians to collaborate on a research study.

The TOPCAT study, sponsored by the National Institutes of Health, is trying to discern whether the potassium-sparing diuretic Spironolactone improves the symptoms of heart failure improve. It involves 4,500 adults over age 50 who have heart failure and a left ventricular ejection fraction of at least 45 percent.

Robert M. Davidson, M.D., a private attending physician, is the primary investigator for the study at Cedars-Sinai. The sub-primary investigator is Ernst R. Schwarz, M.D., Ph.D, medical director of the Cardiac Support Program and co-director of Cardiac Transplantation. Others involved are Mark K. Urman, M.D., also a private attending and co-director of the Heart Center at the Cedars-Sinai Heart Institute and immediate-past clinical chief of the Division of Cardiology; Kiran Philip, M.D., cardiology fellow; and Faramarz Tehrani, M.D., medical resident and future cardiology fellow.

"This is certainly not the first time there have been cooperative studies between the private and full-time physician staff at the medical center," Dr. Davidson said. "However, this is the first time there has been a deliberate effort to do collaborative clinical research as an ongoing long-term project, and it is a new endeavor for the Cedars-Sinai Heart Institute."

Dr. Davidson added that combining of efforts and resources will make it easier to recruit subjects and increase the performance of the trial. Cedars-Sinai is the only medical center in the region participating in the study.

For more information on the study, contact Dr. Davidson at Robert.Davidson@cshs.org.