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PRODUCED BY AND FOR MEMBERS OF THE DEPARTMENT OF SURGERY April 2013 | Archived Issues

Articles Accepted for Publication

The following articles involving members of the Department of Surgery have been accepted for publication:

  • V. Krishnan Ramanujan, PhD (principal investigator): "Mitochondrial NDUFS3 Regulates ROS-mediated Onset of Metabolic Switch in Transformed Cells" (in press), Biology Open (The Company of Biologists, U.K.).
  • Gertych A, Oh JH, Wawrowsky KA, Weisenberger DJ, Tajbakhsh J. 3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models. BMC Pharmacol Toxicol. 2013 Feb 11;14:11. Synopsis: The publication is based on a two-year study performed by the Translational Cytomics Group at Cedars-Sinai in collaboration with the USC Epigenome Center. The investigators succeeded in demonstrating that in situ chromatin textures, simply covisualized by immunofluorescence of nuclear 5-methylcytosine and global DNA and quantitated by sophisticated and dedicated 3D image analysis, correlate with cellular toxicity. The results underline the potential of such signatures to be utilized in the risk assessment of environmental influences as well as therapeutic reprogramming of cancer cells by epigenetic drugs that exert off-target DNA demethylation; with translational applications in environmental health and pre-clinical drug toxicology.

BMC Pharmacology and Toxicology Article - February 2013 (PDF)