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PRODUCED BY AND FOR MEMBERS OF THE DEPARTMENT OF SURGERY January 2013 | Archived Issues

Leon Morgenstern, MD: 1919-2012

Leon Morgenstern, MD, a beloved colleague and the founding director of surgery for Cedars-Sinai Medical Center, died Dec. 23 at his home in Malibu at age 93. A surgeon, scholar, humanist, medical researcher and prolific author, he remained active after his retirement and was working in his Cedars-Sinai office as recently as Dec. 21.

Cedars-Sinai is planning a memorial in his honor.


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Dozens make presentations at Research Day, ACS meeting

Numerous Cedars-Sinai Department of Surgery residents and faculty members made presentations at the medical center's Research Day IV and at the annual meeting of the regional chapter of the American College of Surgeons.

Presentations at Cedars-Sinai Research Day

The Department of Surgery would like to acknowledge all of those who participated in the Cedars-Sinai Research Day IV on Jan. 11. The following posters were presented:

  • Yelena Bykhovskaya, PhD, Ana Laura Caiado Canedo, Kenneth W. Wright, MD, Yaron S. Rabinowitz, MD. "MIR184 c.57C>T mutation is responsible for congenital cataracts and corneal abnormalities in a five-generation family from Galicia, Spain." Presented by Yelena Bykhovskaya, PhD
  • Valentina R. Minciacchi, Matteo Morello, Mirja Rotinen, Mandana Zandian, Julie Yang, Murali Gururajan, Leland W. K. Chung, Michael R. Freeman, Francesca Demichelis, and Dolores Di Vizio."miRNA profiling of prostate cancer cell-derived oncosomes." Presented by Valentina R. Minciacchi
  • Matteo Morello, Valentina R. Minciacchi, Mirja Rotinen, Mandana Zandian, Chia-Yi Chu, Leland W.K. Chung, Marsha A. Moses, Michael R. Freeman, and Dolores Di Vizio. "A new filtration-based method for high-throughput analysis of tumor-derived large oncosomes." Presented by Matteo Morello, PhD
  • Mirja Rotinen, PhD, Matteo Morello, PhD, Mandana Zandian, MD, Michael R. Freeman, PhD, and Dolores Di Vizio, MD, PhD. "ssDNA and dsDNA can be isolated from tumor-derived large oncosomes." Presented by Mirja Rotinen, PhD
  • Mirja Rotinen, PhD, Samantha Morley, PhD, Matteo Morello, PhD, Julie Yang, Jayoung Kim, PhD, Joaquín Villar, PhD, Dolores Di Vizio, MD, PhD, Ignacio Encío, PhD, and Michael R. Freeman, PhD. "Transcriptional regulation of the mediator of the amoeboid phenotype DIAPH3 in prostate cancer cell lines: potential cross-talk between androgen receptor and NF-kB pathways." Presented by Mirja Rotinen, PhD
  • Sungyong You, PhD, Seok Joong Yun, Hyung L. Kim, MD, Edwin Posadas, MD, Beatrice Knudsen, MD, PhD, Massimo Loda, Michael R. Freeman, PhD, Wun-Jae Kim, and Jayoung Kim, PhD. "An EGFR Subcellular Trafficking Network in Chemoresistant Bladder Cancer." Presented by Sungyong You, PhD
  • Sungyong You, PhD, Jennifer Anger, MD, Tack Lee, Susan Keay, Michael R. Freeman, PhD, and Jayoung Kim, PhD. "A Signaling Networking Evoked by the Interstitial Cystitis-Associated Frizzled 8-Related Antiproliferative Factor." Presented by Sungyong You, PhD
  • Sungyong You, PhD, Samantha Morley, PhD, Dolores Di Vizio, MD, PhD, Jayoung Kim, PhD and Michael R. Freeman, PhD. "Microvesicles Shed from DIAPH3-Silenced, Amoeboid Prostate Cancer Cells Enhance Growth of Other Tumor Cells and Suppress Proliferation of Immune Cells." Presented by Sungyong You, PhD
  • Sungyong You, PhD, Julie Yang, Mirja Rotinen, PhD, Samantha Morley, PhD, Michael R. Freeman, PhD, and Jayoung Kim, PhD. "NFAT5 as a Transcriptional Mediator of Mesenchymal-Amoeboid Transition Induced by DIAPH3 Loss in Prostate Cancer." Presented by Sungyong You, PhD
  • Yanping Wang, Hao Zhang and Hyung L Kim. "CD4 depletion enhances the antitumor effect of mTor inhibition." Presented by Yanping Wang
  • Gordon Wu, MD, Ning-Ning Chai, PhD, Irene Kim, MD, Stanley Jordan, MD, and Andrew Klein, MD. "IL6R Blockage by Therapeutic Antibody Suppresses Donor Specific Antibody Responses in a Mouse Model of Allosensitization." Presented by Gordon Wu, MD
  • Thuy B. Tran, Vijay G. Menon, Douglas Liou, Nicholas N. Nissen. "Surgical Management of Advanced Adrenocortical Carcinoma: AJCC Prognostic Factors." Presented by Douglas Liou, MD
  • Vijay G. Menon, MD, Vichin C. Puri, Oscar Garcia, Alagappan A. Annamalai, MD, Nicholas N. Nissen, MD. "Outcomes of Vascular Resection in Pancreaticoduodenectomy." Presented by Vijay Menon, MD
  • Zorica Buser, PhD, Li Zhao, PhD, Yalda Safai, Linda Kanim, Rick Delamarter, MD, Alexander Rasouli, MD. "Inflammatory response after spinal cord injury in rats is modified by Enbrel." Presented by Zorica Buser, PhD
  • Melodie Metzger, PhD, LEA Kanim, Li Zhao, PhD, Samuel T Robinson, Zorica Buser, PhD, Rick Delamarter, MD. "The Relationship Between Serum Vitamin D levels, Successful Fusion, and Fusion Strength: A Quantitative Analysis." Presented by Melodie Metzger, PhD
  • Samuel T Robinson, Rick B Delamarter, MD, Mark T Svet, Melodie F Metzger, PhD. "Does Sacral Geometry Affect Biomechanical Bahavior and Facet Forces after Total Disc Replacement at the Lumbosacral Junction?" Presented by Samuel Robinson
  • Samuel T Robinson, Mark T Svet, Melodie F Metzger, PhD. "Four-Point Bending in Flexion as a Method for Quantitatively Assessing Spinal Fusions." Presented by Samuel Robinson
  • Mark T Svet, Samuel T Robinson, Rick B Delamarter, MD, FL Acosta, DG Drazin, MD, Melodie F Metzger, PhD. "Biomechanical Analysis of the Effect of Different Instrumentation Techniques on Adjacent Level Stability After Long Segment Instrumentation of the Thoracic Spine." Presented by Mark Svet
  • Shiran Ben-David, Dmitriy Sheyn, PhD, Dan Gazit, PhD, DMD, Zulma Gazit, PhD. "Adipose derived stem cells reprogrammed to iPS cells can be efficiently differentiated back to MSCs using a short exposure to TGFb." Presented by Shiran Ben-David
  • Zorica Buser, PhD, Christopher Buser, PhD, Rick Delamarter, MD. "Differentiation of adipose stem cell constructs for intervertebral disc regeneration." Presented by Zorica Buser, PhD
  • Dmitriy Sheyn, PhD, Wafa Tawackoli, PhD, Deuk Soo Jun, MD, Young Do Koh, PhD, Hyun Bae, MD, Xiaoyu Da, Susan Su, PhD, Zulma Gazit, PhD, Gadi Pelled, PhD, DMD, and Dan Gazit, PhD, DMD. "Systemic treatment for multiple lumbar bone defects using combined human MSCs and PTH therapy." Presented by Dmitriy Sheyn, PhD
  • Susan Su, PhD, Dmitriy Sheyn, PhD, Gadi Pelled, PhD, DMD, Dan Gazit, PhD, DMD, and Zulma Gazit, PhD. "Isolation and characterization of mesenchymal stem cells (MSC) from the temporomandibular joint (TMJ) disc." Presented by Susan Su, PhD
  • Dodanim Talavera, MD, PhD, Soshana P. Svendsen, PhD, Clive N. Svendsen, PhD, Vaithi Arumugaswami, PhD, and Donald Dafoe, MD. "In vitro expansion and characterization of insulin-producing cells derived from human pluripotent stem cells co-cultured with endothelial cells." Presented by Dodanim Talavera, MD, PhD
  • Wafa Tawackoli, PhD, Dmitriy Sheyn, PhD, Xiaoyu Da, Gadi Pelled, PhD, DMD, Dan Gazit, PhD, DMD, and Zulma Gazit, PhD. "PTH treatment enhances mesenchymal stem cell differentiation, improving healing process of calvarial bone allografts." Presented by Wafa Tawackoli, PhD

Presentations at the American College of Surgeons chapter meeting

Several Cedars-Sinai faculty members and residents were scheduled to give presentations at the Annual Scientific Meeting of the Southern California Chapter of the American College of Surgeons, Jan. 18-20 in Santa Barbara.

In the General Surgery sessions:

  • "Surgical Instrument Waste after Elective Major Colorectal Surgery: A Prospective Interventional Pilot Study," Zhaoyi Tang
  • "Will Internet-based Education and Reminders Reach Uninsured Hispanic Women?" Catherine Dang, MD
  • "When It's Not a Spigelian Hernia: Abdominal Cutaneous Nerve Entrapment Syndrome," Shirin Towfigh, MD

In the Breast and Oncologic Surgery session:

  • "Surgical Management of Advanced Adrenocortical Carcinoma: AJCC Prognostic Factors," Thuy B. Tran, MD
  • "Paget's Disease with Parenchymal DCIS: A Worse Prognosis than Paget's Disease Alone," Brandice Durkan, MD

In the HPB Surgery session:

  • "Outcomes of Vascular Resection in Pancreaticoduodenectomy," Vijay G. Menon, MD

In the Colorectal Surgery session:

  • "Routine Elective Colectomy Following CT-Guided Percutaneous Drainage of Diverticular Abcess," Seth Felder, MD

In the Breast Surgery session:

  • "Nipple-Sparing Mastectomy: Mainstream but Not Yet Standard of Care," Armando Giuliano, MD, FACS

In the General Surgery/Hernia session:

  • "The Pediatric Patient," Philip Frykman, MD

In the Trauma Surgery session:

  • "Bicycle Trauma: A Ten-Year Experience," Alexandra Gangi, MD

In the Cardiothoracic and Vascular Surgery session:

  • "Video Assisted Thoracoscopic Surgery (VATS): A Viable Approach for the Treatment of Traumatic Hemothorax," Daniel Shouhed, MD
  • "Midodrine use in the Management of Postoperative High Flow Chylothorax," Douglas Liou, MD

In poster sessions:

  • "Laparoscopic Retrograde Cholecystectomy: Valuable Approach in Patients with Underlying Liver or Pancreatic Disease," Vichin C. Puri, MD
  • "Prospective Evaluation of Current Practices of Venous Thromboembolism Prophylaxis Using Heparin After Elective Intestinal Surgery at an Urban Teaching Hospital," Joseph Wend

What’s new in surgery:

  • Neuroendocrine – Nicholas Nissen, MD

Presiding officers from Cedars-Sinai:

  • Daniel R. Margulies, MD (Acute Care Surgery)
  • Edward Phillips, MD (General Surgery)
  • Farin Amersi, MD (Breast and Oncologic Surgery)

Chair from Cedars-Sinai:

  • Shirin Towfigh, MD (General Surgery/Hernia)