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PRODUCED BY AND FOR MEMBERS OF THE DEPARTMENT OF SURGERY August 2017 | Archived Issues

Study Examines Lung Cancer Among Nonsmoking Women

Harmik J. Soukiasian, MD

A new study examines the biology of non-small-cell lung cancer (NSCLC) and new therapeutic molecular targets, focusing on the pathogenesis of non-smoker female NSCLC patients. Harmik J. Soukiasian, MD, director of Division of Thoracic Surgery at Cedars-Sinai, contributed to the study, which was published in Cancer Biology & Therapy earlier this year.

While most lung cancers are a result of smoking, approximately 25 percent of lung cancer cases worldwide are not attributable to tobacco use. Notably, more than half of the lung cancer cases in women occur in nonsmokers.

Among NSCLC cases, cigarette smokers have a greater association with squamous cell carcinoma than adenocarcinoma, which is more common in nonsmokers. These findings imply that specific molecular and pathological features may associate with lung adenocarcinoma arising in non-smoker female patients.

Current status of research and treatment for non small cell lung cancer in never smoking females (PDF)