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PRODUCED BY AND FOR MEMBERS OF THE DEPARTMENT OF SURGERY October 2017 | Archived Issues

Physicians Publish on Stereotactic Body Radiation Therapy

Stereotactic body radiation therapy (SBRT) has demonstrated efficacy comparable to surgery for early stage non-small cell lung cancer (NSCLC), according to a new article authored by several Cedars-Sinai physicians in the International Journal of Radiation Oncology.

Recent preclinical and clinical data indicate that immune-mediated mechanisms drive the efficacy of SBRT, but little is known about the nature of the immune response in the lung. The purpose of the study was to develop an immunocompetent orthotopic murine model of NSCLC for SBRT by combining an intrapleural injection with a small animal irradiation platform in order to study the underlying immunobiology of SBRT for lung tumors.

The article's authors from Cedars-Sinai included Fernando Espinoza-Mercado, MD, Harmik J. Soukiasian, MD, Amin J. Mirhadi, MD, and Zachary S. Zumsteg, MD.